Elucidating the structure of poly dopamine

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Herein, a derivative of DA, 2-(4-methoxy-3-methylphenyl)ethylamine (MOE) that has fewer active sites, is used as a simplified model system to study the polymerization mechanism of DA.Experimental results from UV-Vis spectroscopy, single-molecule force spectroscopy and other measurements indicate that free radical polymerization of MOE occurs under both acidic and alkaline conditions in the presence of a polymerization initiator, APS.For example, in order to prevent inflammation, the use of cationic Zn with high concentration has been incorporated into biomaterials as an anti-inflammatory molecule to trigger immune cells (polymorphonuclear cells, PMNs) in acute responses [12–14].

Centre for Human Tissues and Organs Degeneration and Shenzhen Key Laboratory of Marine Biomedical Materials, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China Fiber and Biopolymer Research Institute, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX 79409, USAReceived ; Revised 7 July 2016; Accepted 11 July 2016Academic Editor: Costantino Del Gaudio Copyright © 2016 Shishu Huang et al.This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering.A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule.

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